KMID : 1084220170240020065
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Journal of Rheumatic Diseases 2017 Volume.24 No. 2 p.65 ~ p.73
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The Future of B-cell Activating Factor Antagonists in the Treatment of Systemic Lupus Erythematosus
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Stohl William
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Abstract
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To review B-cell activating factor (BAFF)-antagonist therapy in systemic lupus erythematosus (SLE), literature was searched using the search words and phrases, ¡°BAFF¡±, ¡°B lymphocyte stimulator (BLyS)¡±, ¡°a proliferation-inducing ligand (APRIL)¡±, ¡°B-cell maturation antigen (BCMA)¡±, ¡°transmembrane activator and calcium-modulating and cyclophilin ligand interactor (TACI)¡±, ¡°BLyS receptor 3 (BR3)¡±, ¡°belimumab¡±, ¡°atacicept¡±, ¡°blisibimod¡±, ¡°tabalumab¡±, and ¡°lupus clinical trial¡±. In addition, papers from the author¡¯s personal library were searched. BAFF-antagonist therapy in SLE has a checkered past, with four late-stage clinical trials meeting their primary endpoints and four failing to do so. Additional late-stage clinical trials are enrolling subjects to address some of the remaining unresolved questions, and novel approaches are proposed to improve results. The BAFF-centric pathway is a proven therapeutic target in SLE. As the only pathway in the past 50+ years to have yielded an United States Food and Drug Administration-approved drug for SLE, it occupies a unique place in the armamentarium of the practicing rheumatologist. The challenges facing clinicians and investigators are how to better tweak the BAFF-centric pathway and improve on the successes realized.
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KEYWORD
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Systemic lupus erythematosus, BAFF, B lymphocyte
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